Gel and enzyme drain cleaners, monthly maintenance packs and drain snakes. Makers in this lineup include Green Gobbler, Instant Power, and Roebic, plus 22 more brands. You will also find Yugou, Thrift, and AC Line.
Most prices land between $27 and $50. Look at the unit count and the size of each item, and keep the directions from the brand handy. Compare pack size and count per container, since many of these items are sold as multi-packs.
From the Household Cleaners aisle; see also All-Purpose Cleaners, Floor Cleaners, Bathroom & Toilet Cleaners, and Carpet & Upholstery Stain Removers. For the wider range, start from Health & Household. Standard shipping costs nothing on any order to a U.S. address, and unused items qualify for a free return for 30 days after delivery.
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Vendor:Sanco Industries
Sanco Industries Root Killer for Sewer and Septic Lines, 2 lb Copper Sulfate Crystals
Sanco Industries Root Destroyer is a 2 lb (0.91 kg) copper sulfate crystal root killer for septic and sewer pipe lines, designed to kill invasive roots without harming the tree. 2 lb (0.91 kg) of copper sulfate crystals — a treatment for invasive roots...- $34.50
- $34.50
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Vendor:Green Gobbler
Green Gobbler Ultimate Main Drain Opener, 64 fl oz, for Tough Clogs
Green Gobbler Ultimate Main Drain Opener is a high-density drain cleaner designed to dissolve tough main-line clogs, with a 64 fl oz (1,893 mL) bottle for use in drains throughout the home. Thick, high-density formula — sinks through water and clings to pipes. Dissolves...- $35.85
- $35.85
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Vendor:Sanco Industries
Sanco Industries Root Killer for Sewer & Septic Lines, 5 lb Copper Sulfate Crystals
Sanco Industries Root Destroyer is a 5 lb (2.27 kg) copper sulfate crystal root killer for sewer and septic lines, formulated to kill roots inside the leach line and help stop new growth. Pure copper sulfate crystals — target invasive roots in sewer and...- $56.41
- $56.41
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Vendor:Drano
Drano EarlyAction Foaming Drain Clog Remover, 17 oz 5-Pack for Sinks & Disposals
Drano EarlyAction Foamer is a foaming drain clog remover and cleaner for slow-running kitchen and bathroom sinks and garbage disposals, supplied as five 17 fl oz (503 mL) bottles. Two ingredients combine after pouring to create foam — helps the cleaner reach pipe walls....- $42.03
- $42.03
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Vendor:AC Line
AC Line HVAC Drain Line Cleaner, 4-Pack 12-Month Supply for Monthly Maintenance
AC Line Drain Line Cleaner is a monthly-use cleaner for HVAC and other condensate drain lines, supplied as a 4-pack with a 12-month supply. Heavy-duty formula — breaks down and reduces buildup linked to clogs and backflow. For drain lines, drip pans, pump reservoirs,...- $42.03
- $42.03
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Vendor:NEWERSOL
NEWERSOL Drain Clog Remover Powder, 18 Individually Wrapped Packs for Home Drains
NEWERSOL Drain Clog Remover is an individually wrapped drain-cleaning powder designed to clear common household clogs, including grease, hair, soap scum, and food debris, from a range of drains. 18 individually wrapped packs — keep portions ready for drain cleaning. Targets grease, hair, soap...- $26.28
- $26.28
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Vendor:Roebic
Roebic Leach & Drain Field Opener Concentrate, 32 oz, Septic Treatment
Roebic K-570-Q is a 32 oz concentrated leach and drain field opener designed to break up clogged or sluggish drain fields and restore proper drainage. All-natural, biodegradable formulation — brings biodegradable bacteria to septic drain field treatment. Aerobic spore-bearing bacteria resistant to soaps and...- $27.63
- $27.63
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Vendor:Nhtrg
Nhtrg Foaming Drain Cleaner & Deodorizer, 2-Piece Set for Clogs and Odors
Nhtrg Foaming Drain Cleaner & Deodorizer is a two-piece foaming drain treatment designed to clear clogs and freshen household drains, including kitchen sinks, bathroom drains and tubs. Two-piece set — provides two units of foaming drain cleaner. Foaming formula — helps clear stubborn blockages...- $37.22
- $37.22
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Vendor:Thrift
Thrift T-200 Odorless Drain Cleaner, 2 lb, Hot-Water Activated for Drain Maintenance
Thrift T-200 is a professional-strength, odorless drain cleaner for maintaining drain flow, with a non-acid formula activated by hot water and a 2 lb (0.91 kg) size. Helps dissolve grease, hair, soap scum, and organic waste — addresses common drain buildup. Activated by hot...- $35.87
- $35.87
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Vendor:Roto-Rooter
Roto-Rooter Enzyme Drain Cleaner, 64 oz Build-Up Remover for Septic-Safe Plumbing Care
Roto-Rooter Build-Up Remover is an enzyme-based drain cleaner for routine plumbing maintenance, in a 64 oz size designed to help reduce buildup and support free-flowing drains over time. Enzyme-based formula — helps break down residue inside pipes over time. Targets grease, soap residue, and...- $26.28
- $26.28
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Vendor:AC Line
AC Line Drain Line Cleaner, 2-Pack, 6-Month Supply for HVAC Condensate Lines
AC Line AC Drain Line Cleaner is a monthly-use cleaner for HVAC and other condensate drain lines, supplied as a 2-pack with a 6-month supply. Heavy-duty formula breaks down and reduces buildup — helps address buildup linked to clogging and backflow. For central AC,...- $27.06
- $27.06
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Vendor:Green Gobbler
Green Gobbler Powder Plunger Toilet Clog Remover, 2 Pack, 16.5 oz for Tough Clogs
Green Gobbler Powder Plunger is a toilet clog remover made to break down tough clogs and slow-moving drains, supplied as a 2-pack with a net weight of 16.5 oz (468 g). 2-pack, net weight 16.5 oz (468 g) — provides a ready supply for...- $29.02
- $29.02
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Vendor:Yugou
Yugou Foaming Drain Cleaner and Deodorizer, Lavender 2-Piece Set for Household Drains
Yugou Foaming Sink Drain Cleaner Deodorizer & Clog Remover is a lavender-scented, two-piece drain-care set designed to help reduce everyday buildup and unpleasant drain odors with expanding foam. Expanding foam reaches into drain walls and pipes — helps break down everyday buildup. Made for...- $37.22
- $37.22
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Vendor:Leak Saver
Leak Saver HVAC Drain Pan Treatment Tablets, 200 Count Flow Treat for Odor and Clog Control
Leak Saver HVAC GUYS Flow Treat Tabs are HVAC condensate-drain treatment tablets designed to help keep drain pans clear, control odors, and reduce clog-related overflow, with 200 tablets and up to four weeks of treatment per tablet. Quaternary Ammonia Technology — helps control residue...- $42.66
- $42.66
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Vendor:iFLO
iFLO Smart AC Drain Line Cleaner Cartridge, 36 oz, 6-Month Supply with Bio-Enzymatic Formula
iFLO Smart AC Drain Line Cleaner Cartridge is a bio-enzymatic concentrate for maintaining HVAC drain lines, with one 36 oz bottle providing up to six months of cleaning. Up to six months of supply per bottle — reduces how often the cartridge needs replacing....- $56.41
- $56.41
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Vendor:Green Gobbler
Green Gobbler Drain Clog Remover Powder, 5 Packets & 5 Tools, Bleach-Free Pipe-Safe Formula
Green Gobbler Drain Clog Remover & Drain Cleaner Powder is a powder kit designed to break up 20+ drain clogs, with five packets and five tools for home plumbing use. Use one scoop per clogged drain — a measured amount makes dosing straightforward. Let...- $31.74
- $31.74
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Vendor:Accelerator by Dr. Pooper
Accelerator by Dr. Pooper Drain Cleaner Powder, 32 oz, Septic-Safe for Household Drains
Accelerator by Dr. Pooper Drain Cleaner & Maintenance is a powdered drain cleaner for clearing organic clogs, built-up grease and odors, supplied in a 32 oz (907 g) jar with a scoop. Targets organic clogs and grease in drain pipes — helps restore proper...- $56.39
- $56.39
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Vendor:Thrift
Thrift Granular Drain Cleaner, 2-Pack of 1-Pound Bottles, Hot-Water Activated
Thrift T-100 is an alkaline-based granular drain cleaner for plumbing maintenance, supplied as two 1-pound bottles and activated with hot water. Two 1-pound bottles — a 2-pack for residential, commercial, and professional plumbing maintenance. Hot-water-activated crystals — designed to liquefy grease, hair, soap scum,...- $35.87
- $35.87
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Vendor:SANI 360°
SANI 360° Enzyme Drain Cleaner and Odor Remover, Lemon, 16 Uses
SANI 360° is a ready-to-use enzyme drain cleaner and odor remover for drain maintenance, with 16 uses per product and a fresh lemon scent. Thickened gel formula — carries the cleaner to the area where buildup collects. Enzyme action — breaks down organic waste...- $35.87
- $35.87
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Vendor:Unloshe
Unloshe Foaming Drain Cleaner for Sinks and Tubs, 2-Piece Set, Deodorizing No-Scrub Care
Unloshe Foaming Drain Cleaner and Deodorizer is a two-piece set for routine household drain care, using foaming action to help clean drain areas and freshen them. Two-piece set — includes two drain-cleaning products for household maintenance. Foaming action — works through the drain area...- $37.24
- $37.24
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Vendor:HELIX LABORATORIES, INC.
HELIX LABORATORIES, INC. Enzyme Drain Cleaner & Deodorizer, 32 oz BioFresh, Up to 16 Treatments
HELIX LABORATORIES, INC. BioFresh is an enzyme drain cleaner and deodorizer made to break down organic waste and odors, with a concentrated 32 oz (946 mL) bottle providing up to 16 treatments. Natural bacteria cultures break down odors and organic waste — for drain...- $35.81
- $35.81
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Vendor:Cabin Obsession
Cabin Obsession Enzyme Cleaner for Pet Stains, Odors and Drains, 1 Gallon
Cabin Obsession Enzyme Cleaner is a 1-gallon (3.785 L) multi-purpose formula made with natural bacteria and enzymes to tackle pet messes, household odors, and organic drain buildup. Ultra-concentrated formula — made for everyday cleaning in pet-loving households. Enzyme action on pet accidents — targets...- $35.87
- $35.87
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Vendor:Qwatuy
Qwatuy Drain Clog Remover Powder, 4-Pack 480g Foaming Pipe Cleaner
Qwatuy Drain Clog Remover is a foaming powder for clearing household drain blockages, supplied as a 4-pack with 480g of product. Concentrated powder foams when mixed with water — helps break down hair, grease, food scraps and organic buildup. Made for kitchen sinks, bathroom...- $31.76
- $31.76
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Vendor:Amazing Products
Amazing Products Liquid Fire Drain Line Opener, 32 oz, Fast-Acting Heat Action
Amazing Products Liquid Fire Drain Line Opener is a 32 oz drain cleaner designed to clear clogged or slow-running lines in sinks, tubs, shower stalls, septic tanks, and laterals. Works in household drains and septic systems — serves several common drain-line applications. Reacts instantly...- $27.61
- $27.61
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